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qsbr_rw1

qsbr_rw1

active ARFF Publicly available Visibility: public Uploaded 28-09-2014 by Joaquin Vanschoren
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Author: Source: Unknown - Date unknown Please cite: This is one of 41 drug design datasets. The datasets with 1143 features are formed using Adriana.Code software (www.molecular-networks.com/software/adrianacode). The molecules and outputs are taken from the original studies (see below). The other datasets are taken exactly from the original studies. The last attribute in each file is the target. Original studies: carbolenes "B. D. Silverman and Daniel. E. Platt, J. Med. Chem. 1996, 39, 2129-2140" mtp2 "Bergstrom, C. A. S.; Norinder, U.; Luthman, K.; Artursson, P. Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs. J. Chem. Inf. Comput. Sci.; (Article); 2003; 43(4); 1177-1185" chang, cristalli, depreux, doherty, garrat2, garrat, heyl, krystek, lewis, penning, rosowsky, siddiqi, stevenson, strupcz, svensson, thompson, tsutumi, uejling, yokoyama1, yokoyama2 "David E Patterson, Richard D Cramer, Allan M Ferguson, Robert D Clark, Laurence W Weinberger. Neighbourhood Behaviour: A Useful Concept for Validation of ""Molecular Diversity"" Descriptors. J. Med. Chem. 1996 (39) 3049 - 3059." mtp "Karthikeyan, M.; Glen, R.C.; Bender, A. General melting point prediction based on a diverse compound dataset and artificial neural networks. J. Chem. Inf. Model.; 2005; 45(3); 581-590" benzo32 "Harrison,P.W. and Barlin,G.B. and Davies,L.P. and Ireland,S.J. and Matyus,P. and Wong,M.G., Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor, European Journal of Medicinal Chemistry, (31), 1996, 651-662" PHENETYL1 "H. Kubinyi (Ed.): ""QSAR: Hansch Analysis and Related Approaches"", VCH, Weinhein (Ger), 1993, pp.57-68" pah "Todeschini, R.; Gramatica, P.; Marengo, E.; Provenzani, R. Weighted Holistic Invariant Molecular Descriptors. Part 2. Theory Development and Applications on Modeling Physico-Chemical Properties of PolyAromatic Hydrocarbons (PAH). Chemom. Intell. Lab. Syst. 1995, 27, 221-229." pdgfr "R. Guha and P. Jurs. The Development of Linear, Ensemble and Non-linear Models for the Prediction and Interpretation of the Biological Activity of a Set of PDGFR Inhibitors. J. Chem. Inf. Comput. Sci. 2004, 44 (6), 2179-2189" Phen "Cammarata, A. Interrelationship of the Regression Models Used for Structure-Activity Analyses. J. Med. Chem. 1972, 15, 573-577" topo_2_1, yprop_4_1 "Jun Feng et al, Predictive Toxicology: Benchmarking Molecular Descriptors and Statistical Methods, J. Chem. Inf Comput. Sci., 2003 (43) 1463-1470" qsabr1, qsabr2 "Damborsky, J., Schultz, T.W., Comparison of the QSAR models for toxicity and biodegradability of anilines and phenols, Chemosphere 34: 429-446, 1997" qsartox "Blaha, L., Damborsky, J., Nemec, M., QSAR for acute toxicity of saturated and unsaturated halogenated aliphatic compounds, Chemosphere 36: 1345-1365, 1998" qsbr_rw1 "Damborsky, J. et al., Structure-biodegradability relationships for chlorinated dibenzo-p-dioxins and dibenzofurans, In: Wittich, R.-M., Biodegradation of dioxins and furans, R.G. Landes Company, Austin, 1998" qsbr_y2 "Damborsky, J. et al., A mechanistic approach to deriving QSBR- A case study: dehalogenation of haloaliphatic compounds, In: Peijnenburg, W.J.G.M., Damborsky, J., Biodegradability Prediction, Kluwer Academic Publishers" qsbralks "Damborsky, J. et al., Mechanism-based Quantitative Structure-Biodegradability Relationships for hydrolytic dehalogenation of chloro- and bromo-alkenes, Quantitative Structure-Activity Relationships 17: 450-458, 1998" qsfrdhla "Damborsky, J., Quantitative structure-function relationships of the single-point mutants of haloalkane dehalogenase: A multivariate approach, Qunatitative Structure-Activity Relationships 16: 126-135, 1997" qsfsr1 "Damborsky, J., Quantitative structure-function and structure-stability relationships of purposely modified proteins, Protein Engineering 11: 21-30, 1998" qsfsr2 "Damborsky, J., Quantitative structure-function and structure-stability relationships of purposely modified proteins, Protein Engineering 11: 21-30, 1998" qsprcmpx "Cajan, M. et al., Stability of Aromatic Amides with Bromide Anion: Quantitative Structure-Property Relationships, Journal of Chemical Information and Computer Sciences, in press, 2000" selwood "Selwood, D. L.; Livingstone, D. J.; Comley, J. C.; O'Dowd, A. B.; Hudson, A. T.; Jackson, P.; Jandu, K. S.; Rose, V. S.; Stables, J. N. Structure-Activity Relationships of Antifilarial Antimycin Analogues: A Multivariate Pattern Recognition Study J. Med. Chem., 1990, 33, 136-142"

51 features

oz51 (target)numeric14 unique values
0 missing
oz1numeric8 unique values
0 missing
oz2numeric8 unique values
0 missing
oz3numeric14 unique values
0 missing
oz4numeric14 unique values
0 missing
oz5numeric14 unique values
0 missing
oz6numeric14 unique values
0 missing
oz7numeric14 unique values
0 missing
oz8numeric14 unique values
0 missing
oz9numeric14 unique values
0 missing
oz10numeric13 unique values
0 missing
oz11numeric8 unique values
0 missing
oz12numeric12 unique values
0 missing
oz13numeric9 unique values
0 missing
oz14numeric14 unique values
0 missing
oz15numeric14 unique values
0 missing
oz16numeric14 unique values
0 missing
oz17numeric14 unique values
0 missing
oz18numeric14 unique values
0 missing
oz19numeric14 unique values
0 missing
oz20numeric14 unique values
0 missing
oz21numeric14 unique values
0 missing
oz22numeric14 unique values
0 missing
oz23numeric14 unique values
0 missing
oz24numeric12 unique values
0 missing
oz25numeric11 unique values
0 missing
oz26numeric12 unique values
0 missing
oz27numeric13 unique values
0 missing
oz28numeric11 unique values
0 missing
oz29numeric14 unique values
0 missing
oz30numeric11 unique values
0 missing
oz31numeric13 unique values
0 missing
oz32numeric14 unique values
0 missing
oz33numeric14 unique values
0 missing
oz34numeric14 unique values
0 missing
oz35numeric14 unique values
0 missing
oz36numeric13 unique values
0 missing
oz37numeric13 unique values
0 missing
oz38numeric14 unique values
0 missing
oz39numeric13 unique values
0 missing
oz40numeric14 unique values
0 missing
oz41numeric14 unique values
0 missing
oz42numeric13 unique values
0 missing
oz43numeric14 unique values
0 missing
oz44numeric14 unique values
0 missing
oz45numeric14 unique values
0 missing
oz46numeric14 unique values
0 missing
oz47numeric14 unique values
0 missing
oz48numeric13 unique values
0 missing
oz49numeric14 unique values
0 missing
oz50numeric14 unique values
0 missing

107 properties

14
Number of instances (rows) of the dataset.
51
Number of attributes (columns) of the dataset.
0
Number of distinct values of the target attribute (if it is nominal).
0
Number of missing values in the dataset.
0
Number of instances with at least one value missing.
51
Number of numeric attributes.
0
Number of nominal attributes.
-0.01
Mean skewness among attributes of the numeric type.
0.3
First quartile of standard deviation of attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.REPTree -L 2
Error rate achieved by the landmarker weka.classifiers.lazy.IBk -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Area Under the ROC Curve achieved by the landmarker weka.classifiers.lazy.IBk
Kappa coefficient achieved by the landmarker weka.classifiers.trees.J48 -C .001
0.33
Mean standard deviation of attributes of the numeric type.
Second quartile (Median) of entropy among attributes.
Error rate achieved by the landmarker weka.classifiers.trees.REPTree -L 2
Kappa coefficient achieved by the landmarker weka.classifiers.lazy.IBk -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Error rate achieved by the landmarker weka.classifiers.lazy.IBk
Percentage of instances belonging to the most frequent class.
Minimal entropy among attributes.
-1.23
Second quartile (Median) of kurtosis among attributes of the numeric type.
Kappa coefficient achieved by the landmarker weka.classifiers.trees.REPTree -L 2
Entropy of the target attribute values.
Kappa coefficient achieved by the landmarker weka.classifiers.lazy.IBk
Number of instances belonging to the most frequent class.
-2.16
Minimum kurtosis among attributes of the numeric type.
0.49
Second quartile (Median) of means among attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.REPTree -L 3
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.DecisionStump
Maximum entropy among attributes.
0.26
Minimum of means among attributes of the numeric type.
Second quartile (Median) of mutual information between the nominal attributes and the target attribute.
Error rate achieved by the landmarker weka.classifiers.trees.REPTree -L 3
Error rate achieved by the landmarker weka.classifiers.trees.DecisionStump
2.61
Maximum kurtosis among attributes of the numeric type.
Minimal mutual information between the nominal attributes and the target attribute.
0.03
Second quartile (Median) of skewness among attributes of the numeric type.
Kappa coefficient achieved by the landmarker weka.classifiers.trees.REPTree -L 3
Kappa coefficient achieved by the landmarker weka.classifiers.trees.DecisionStump
0.74
Maximum of means among attributes of the numeric type.
The minimal number of distinct values among attributes of the nominal type.
0
Percentage of binary attributes.
0.32
Second quartile (Median) of standard deviation of attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.RandomTree -depth 1
3.64
Number of attributes divided by the number of instances.
Maximum mutual information between the nominal attributes and the target attribute.
-1.51
Minimum skewness among attributes of the numeric type.
0
Percentage of instances having missing values.
Third quartile of entropy among attributes.
Error rate achieved by the landmarker weka.classifiers.trees.RandomTree -depth 1
Number of attributes needed to optimally describe the class (under the assumption of independence among attributes). Equals ClassEntropy divided by MeanMutualInformation.
The maximum number of distinct values among attributes of the nominal type.
0.24
Minimum standard deviation of attributes of the numeric type.
0
Percentage of missing values.
-0.48
Third quartile of kurtosis among attributes of the numeric type.
0.79
Average class difference between consecutive instances.
Kappa coefficient achieved by the landmarker weka.classifiers.trees.RandomTree -depth 1
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.J48 -C .00001
1.65
Maximum skewness among attributes of the numeric type.
Percentage of instances belonging to the least frequent class.
100
Percentage of numeric attributes.
0.55
Third quartile of means among attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.DecisionStump -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.RandomTree -depth 2
Error rate achieved by the landmarker weka.classifiers.trees.J48 -C .00001
0.45
Maximum standard deviation of attributes of the numeric type.
Number of instances belonging to the least frequent class.
0
Percentage of nominal attributes.
Third quartile of mutual information between the nominal attributes and the target attribute.
Error rate achieved by the landmarker weka.classifiers.trees.DecisionStump -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Error rate achieved by the landmarker weka.classifiers.trees.RandomTree -depth 2
Kappa coefficient achieved by the landmarker weka.classifiers.trees.J48 -C .00001
Average entropy of the attributes.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.bayes.NaiveBayes
First quartile of entropy among attributes.
0.26
Third quartile of skewness among attributes of the numeric type.
Kappa coefficient achieved by the landmarker weka.classifiers.trees.DecisionStump -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Kappa coefficient achieved by the landmarker weka.classifiers.trees.RandomTree -depth 2
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.J48 -C .0001
-0.95
Mean kurtosis among attributes of the numeric type.
Error rate achieved by the landmarker weka.classifiers.bayes.NaiveBayes
-1.63
First quartile of kurtosis among attributes of the numeric type.
0.37
Third quartile of standard deviation of attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.bayes.NaiveBayes -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.RandomTree -depth 3
Error rate achieved by the landmarker weka.classifiers.trees.J48 -C .0001
0.5
Mean of means among attributes of the numeric type.
Average mutual information between the nominal attributes and the target attribute.
Kappa coefficient achieved by the landmarker weka.classifiers.bayes.NaiveBayes
0.45
First quartile of means among attributes of the numeric type.
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.REPTree -L 1
Error rate achieved by the landmarker weka.classifiers.bayes.NaiveBayes -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Error rate achieved by the landmarker weka.classifiers.trees.RandomTree -depth 3
Kappa coefficient achieved by the landmarker weka.classifiers.trees.J48 -C .0001
An estimate of the amount of irrelevant information in the attributes regarding the class. Equals (MeanAttributeEntropy - MeanMutualInformation) divided by MeanMutualInformation.
0
Number of binary attributes.
First quartile of mutual information between the nominal attributes and the target attribute.
Error rate achieved by the landmarker weka.classifiers.trees.REPTree -L 1
Kappa coefficient achieved by the landmarker weka.classifiers.bayes.NaiveBayes -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Kappa coefficient achieved by the landmarker weka.classifiers.trees.RandomTree -depth 3
Area Under the ROC Curve achieved by the landmarker weka.classifiers.trees.J48 -C .001
Average number of distinct values among the attributes of the nominal type.
-0.3
First quartile of skewness among attributes of the numeric type.
Kappa coefficient achieved by the landmarker weka.classifiers.trees.REPTree -L 1
Area Under the ROC Curve achieved by the landmarker weka.classifiers.lazy.IBk -E "weka.attributeSelection.CfsSubsetEval -P 1 -E 1" -S "weka.attributeSelection.BestFirst -D 1 -N 5" -W
Standard deviation of the number of distinct values among attributes of the nominal type.
Error rate achieved by the landmarker weka.classifiers.trees.J48 -C .001

13 tasks

0 runs - estimation_procedure: 10-fold Crossvalidation - evaluation_measure: mean_absolute_error - target_feature: oz51
0 runs - estimation_procedure: 10 times 10-fold Crossvalidation - evaluation_measure: mean_absolute_error - target_feature: oz51
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
0 runs - estimation_procedure: 50 times Clustering
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